What does Object Drug metabolism mean?
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What does drug metabolism mean?
The conversion of drugs into new more polar compounds by chemical changes with the effect of enzymes in the organism is called biotransformation or metabolism.
How many stages does drug metabolism consist of?
METABOLISM REACTIONS Metabolism reactions are classified as Phase 1 functionalization and Phase 2 synthesis (conjugation).
How does the biotransformation of drugs occur? ?
Biotransformation, known as drug metabolism, is the chemical changes of drug enzymes in the body. Medicines are substances that are used in various ways to cure the disease. The transformation of a drug into highly effective compounds by being affected by enzymes is called bioactivation.
Drugs are most metabolized from which organ?
The drug is chemically metabolized by the liver or other tissues. It is converted into other substances (metabolites). The LIVER oxidase enzyme system (also known as microsomal enzymes or cytochrome p450 enzymes) is responsible for inactivating (detoxifying) various chemical substances entering the body.
To which protein do drugs bind most in plasma?
< p>Binding to plasma proteins: The primary parameter determining the distribution is the rate of binding to plasma proteins. This binding is mostly with albumin. The most important feature of attachment is that it is nonselective and reversible. As an exception, the bond between alkylating drugs and plasma proteins is the covalent bond (the strongest bond).What is a metabolite? The molecule that turns into a drug as a result is called a metabolite.
From which organ are drugs excreted?
Many drugs and their metabolites are eliminated from the body through the kidneys. Some drugs and their metabolites are excreted from the liver to the intestine via bile.
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